Mansion holiday rentals in Panama
Find and book unique mansions on Airbnb
Top-rated mansion rentals in Panama
Guests agree: these mansions are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama mansion rentals
Luxury mansion rentals
Flat in Panama City
4.84 out of 5 average rating, 31 reviewsPenthouse deluxe, 360º views and glass pool
Villa in Buenaventura, El Chirú
4.84 out of 5 average rating, 45 reviewsLake House | Pool | King Beds | Next to Beach Club
Villa in Panamá
5.0 out of 5 average rating, 32 reviewsBreathtaking Views Mansion w/King Beds
Home in Río Hato
4.95 out of 5 average rating, 75 reviewsSpectacular beachfront house in Buenaventura!
Villa in Playa Venao
4.98 out of 5 average rating, 61 reviewsCasa Aqua: Amazing beach front house - Playa Venao
Flat in Maria Chiquita
4.95 out of 5 average rating, 21 reviewsPenthouse in Playa Escondida 4 bedrooms
Villa in Bejuco
4.96 out of 5 average rating, 78 reviewsBeach house in Punta Chame, Villa frente al mar
Villa in Punta Chame
4.92 out of 5 average rating, 13 reviewsFREE NIGHT Amazing Beachfront Villa - Palm House
Pet-friendly mansion rentals
Home in Playa Bluff
5.0 out of 5 average rating, 16 reviewsJungle House 100m from the beach
Home in Río Hato
4.98 out of 5 average rating, 96 reviewsComplete House for a Perfect Stay
Villa in Portobelo
5.0 out of 5 average rating, 42 reviewsEntire Villa with pool in front of beach!
Flat in San Carlos District
4.99 out of 5 average rating, 79 reviewsAmazing Oceanfront apartment in San Carlos
Home in Gamboa
4.86 out of 5 average rating, 88 reviewsBirdHouse@ Gamboa Panamá Canal
Home in San José
5.0 out of 5 average rating, 19 reviewsαlkeyler| Luxury Mini Resort 12 PERS @Punta Barco
Villa in Bocas del Toro
5.0 out of 5 average rating, 56 reviewsCasa del Mar - eco aqua villa
Villa in Costa Esmeralda
4.97 out of 5 average rating, 70 reviews#1 Villa with pool, jacuzzi, pool table, ping pong.
Mansion rentals with a pool
Villa in Río Hato
5.0 out of 5 average rating, 38 reviewsLuxury 4BR Villa + Guesthouse & Pool @Buenaventura
Apartment in Maria Chiquita
5.0 out of 5 average rating, 19 reviewsPlaya Escondida Lux Beachfront Haven:Oceanview Apt
Flat in Maria Chiquita
4.97 out of 5 average rating, 61 reviewsSpacious 4Br Beachside Getaway at Playa Escondida
Flat in Panamá
5.0 out of 5 average rating, 21 reviewsTop Floor Condo 6 bedroom with amazing views
Flat in Río Hato
5.0 out of 5 average rating, 18 reviews4 Bedroom Private Pool Paradise in Buenaventura
Flat in Panama City
4.94 out of 5 average rating, 18 reviews22M Spectacular Penthouse New Design Oceanview
Flat in El Chirú
4.94 out of 5 average rating, 85 reviewsBuenaventura Golf & Beach Resort Lux Apartment
Flat in María Chiquita
4.94 out of 5 average rating, 67 reviewsPlaya Escondida Resort & Marina
Destinations to explore
- Villa rentals Panama
- Apartment rentals Panama
- Rentals with lake access Panama
- Flat rentals Panama
- Family-friendly rentals Panama
- Farm stay rentals Panama
- Chalet rentals Panama
- Private suite rentals Panama
- Rentals with an accessible-height bed Panama
- Rentals with a patio Panama
- Rentals with a firepit Panama
- Guest house rentals Panama
- Rentals with a washing machine and dryer Panama
- Boat rentals Panama
- Bed and breakfasts Panama
- Smoking-friendly rentals Panama
- Rentals with beach access Panama
- Cabin rentals Panama
- Rentals with outdoor seating Panama
- Rentals with a fireplace Panama
- Bungalow rentals Panama
- Beachfront rentals Panama
- Rentals with a kayak Panama
- Rentals with a sauna Panama
- Beach apartment rentals Panama
- Treehouse rentals Panama
- Cottage rentals Panama
- Monthly Rentals Panama
- Rentals with a cinema Panama
- Boutique hotel rentals Panama
- Fitness-friendly rentals Panama
- Rentals with an EV charger Panama
- Hostel rentals Panama
- Loft rentals Panama
- Rentals with pools Panama
- Waterfront rentals Panama
- Rentals with breakfast Panama
- Family-friendly rentals Panama
- Tiny house rentals Panama
- Townhouse rentals Panama
- Holiday home rentals Panama
- Pet-friendly rentals Panama
- Rentals with a hot tub Panama
- Wheelchair-accessible rentals Panama
- Nature eco lodge rentals Panama
- Hotel rentals Panama
- House rentals Panama
- Island rentals Panama
- Beach house rentals Panama
- Serviced apartment rentals Panama
- Ski-in/ski-out rentals Panama
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom